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Pooled analysis including these two studies in addition to SELECT and FLOW [31] reported that semaglutide reduced the risk of hospitalization or urgent visits due to heart failure by 41% (HR 0.59, 95% CI 0.410.82) in HFpEF patients compared with placebo [32]

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(Marso et al., NEJM, 2016) Tirzepatide: the dual-agonist advantage Tirzepatide simultaneously agonises GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors