T2DM is characterized by a chronic proinflammatory state marked by the overexpression of cytokines, such as interleukin-1, interleukin-6, and tumor necrosis factor-alpha, alongside chemokines and other proinflammatory mediators, which contribute to insulin resistance.108 Elevated concentrations of these inflammatory cytokines have been detected in the plasma and cerebrospinal fluid of patients with AD,109 and postmortem analyses revealed an inflammatory milieu within the AD brain,110 implicating inflammation as a contributory factor in the pathogenesis of dementia
If you are overweight, specifically having increased visceral adiposity, you are diabetic or you have pre-diabetes, again, go back to the insulin, uh, show
Wang M, Yoon G, Song J, Jo J
That might mean allowing downregulated receptors to recover their sensitivity
[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Mller T.D., Finan B., Bloom S.R., D'Alessio D., Drucker D.J., Flatt P.R., et al
