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The neuroprotective effects align with BDNF-supporting mechanisms, including reduced hippocampal lipid peroxidation

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The upstream regulators of TRAF3IP2 include oxidative stress, RAAS activation and cytokines, including IL-17, whereas the downstream targets are transcriptional factors, such as NF-B and AP-1 and cell signaling pathways such as p38-MAPK and the crosslinking enzyme, lysyl oxidase [189] (Fig