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These effects may be achieved by lowering HR or by acting directly on -adrenergic receptors in VSMCs to relax the vessel tone or reduce catecholamine release from post-ganglionic sympathetic neurons (215)

10.1038/emm.2017.207 Exp Mol Med

F.JessenH.Nhr-MeldgaardJ.BuchB

Borner MM, Schoffski P, de Wit R, Caponigro F, Comella G, Sulkes A et al (2002) Patient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and leucovorin: a randomised crossover trial in advanced colorectal cancer

These mechanistic actions have been consistently verified in various disease models, including atherosclerosis, intestinal ischemiareperfusion injury (IIRI), and pulmonary ischemiareperfusion injury (LIRI) [341,342,343]