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The app guides dose ramp-up schedules, dose change reminders, and prompts to pause escalation when symptoms appear

They typically give mega-doses (10-25 mg) to help those with significant B12 deficiency symptoms

Intervention Participants received semaglutide (0.25 mg/week for 4 weeks, 0.5 mg/week for 4 weeks, and 1.0 mg for 1 week) or placebo at weekly clinic visits

In addition, GLP-1 can stimulate the epidermal growth factor (EGF), triggering the phosphatidylinositol-3 kinase (PI3K), which activates transcription factors associated with -cell growth while inhibiting those linked to -cell apoptosis (18)