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iScience 26 , 107487 (2023)

The most common adverse events with orforglipron were gastrointestinal in nature and included nausea, diarrhea, constipation, vomiting and dyspepsia

If blood sugar targets are not being met effectively on one medication, the dual action of tirzepatide might provide superior glucose management

These two enzymes are part of the nitrogen and nicotinate/nicotinamide metabolic pathways, which have been identified in our previous studies as potentially playing an important role in C

Begin with a small amount of fibre supplement (perhaps one-quarter to one-half of the recommended dose) and increase slowly over two to four weeks