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However, application of JA to Na 2 CO 3 fed plants showed a 17.29 and 21.36% reduction in lipid peroxidation at 100 mM Na 2 CO 3 + 10 M JA and 150 mM Na 2 CO 3 + 10 M JA, respectively, as compared to only alkaline-stressed plants at 100 and 150 mM Na 2 CO 3 , respectively

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This concept highlights the intricate, bidirectional communication among the gastrointestinal tract, the central nervous system (CNS), and the kidneys where dysfunction in one system can lead to cascading effects on the others (Yang et al., 2018)

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However, gastrointestinal side effects are also one of the main reasons some patients stop taking semaglutide