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Against Phentermine/Topiramate, Tirzepatide demonstrated a significant association only with dry eye disease (HR 0.29, 95% CI: 0.150.57, p = 1.3 10 4 ), while other outcomes including cataracts (HR 0.76, 95% CI: 0.381.52, p = 0.433) and oculomotor binocular dysfunction (HR 0.63, 95% CI: 0.341.16, p = 0.134) showed non-significant trends

And it optimises the three-dimensional conformation of the peptide for high-affinity binding to the mu-opioid receptor

[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Galtier N, Enard D, Radondy Y, Bazin E, Belkhir K

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Key Safety Considerations Appetite Control: Wegovy reduces hunger and promotes fullness, whereas cannabis may stimulate appetite