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The USC study came with some major caveats however: It assumed 100 percent uptake, perfect compliance, and continual use by beneficiaries for the rest of their lives conditions that are not achievable in practice, to quote CBO

Weight Regain: A Common Issue One of the primary challenges faced by patients discontinuing GLP-1 medications is the significant risk of weight regain

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Furthermore, pre-synaptic and post-synaptic proteins, synaptophysin and PSD-95, which reflect synaptic disruption [122], were upregulated, neuronal excitability normalized, and intracellular calcium, a key regulator in metabolic dysfunction and progressive neuronal loss [123], was modulated [121]