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For cardiac tissue support, TB-500 has the stronger evidence base

In addition to GLP-1 Support providing 5 grams of marine hydrolyzed collagen peptides that contain essential amino acids, it provides 3 grams of the nine essential amino acids (leucine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine)

Topical peptides are useful for certain applications (GHK-Cu copper peptide has reasonable evidence for topical activity), but for the major therapeutic peptides growth hormone secretagogues, BPC-157, Epithalon systemic delivery is required to produce the effects seen in the research literature

That calcium signal is necessary for normal brain function, but excessive NMDAR activity creates excitatory pressure