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GI symptoms, dehydration, edema, numbness, sleep apnea symptoms, and severe abdominal pain need symptom-based review

A 2015 meta-analysis of 15 trials (1,106 patients) confirmed that IV methylcobalamin (5001,500 mcg/day) combined with alpha-lipoic acid improved nerve conduction velocity by 2030% more than monotherapy, reducing tingling and burning sensations

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This is critical because injured tendons, ligaments, and damaged gut mucosa have poor blood supply

The chief activator of AMPK is the serine-threonine tumor suppressor kinase LKB1, which contributes to phosphorylation of AMPK to activate energy sensors (235, 238)