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The hub genes were HMOX1, SPP1, CCR2, DCN, IRS1, and IGF1

Side effects and safety concerns The combination amplifies risks significantly

Mechanistically, metformin prolongs lifespan mainly by activating AMPK to inhibit the SASP

The list of prescription medications used by individual participants and comorbidities can be found in Supplementary Table 1

this indicates that bromfenvinfos caused cell shrinkage and phospholipid mixing in the erythrocyte cell membrane, which is partly due to stimulation of ROS formation and Ca 2+ entry [437]