In addition, dapagliflozin attenuated the progression of diabetic cardiomyopathy by activating AMPK, mTOR and NOD-like receptor 3 (NLRP3) inflammasome in T2DM mice [105]
A meta-analysis of incident MACE in the Phase III tirzepatide clinical trial programme for type 2 diabetes revealed evidence for cardiovascular safety and numerically fewer MACE events in people randomised to tirzepatide therapy [126]
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Moreover, SCFAs, dose-dependently, which effects dependent on the specific SCFA, segment of the colon animal species and experimental models, may impact IBS-D with increased transit rate