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In the presence of GSH, GPX4 mediates the conversion of toxic LPOs to nontoxic lipid alcohols

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Moreover, A double-blind study of patients with T2DM treated with metformin led to significant changes in the relative abundance of more than 80 bacterial species compared with placebo after 4 months, in which an increase in Escherichia and Akkermansia muciniphila and a decrease in Intestinibacter were also observed, whereas most of the changes with placebo occurred in phylum Firmicutes and phylum Proteobacteria (Wu et al., 2017)

PALL), before loading on a 1-ml Ni-NTA column (Cytiva)

10.1152/ajpendo.00324.2003 [DOI] [PubMed] [Google Scholar] 93.Cataln V, Gmez-Ambrosi J, Rodrguez A, Silva C, Rotellar F, Gil MJ, et al