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Hyperuricemia Predisposes to the Onset of Diabetes via Promoting Pancreatic -Cell Death in Uricase-Deficient Male Mice

HFD impairs liver glutathione biosynthesis, vitamin D metabolism genes and genes associated with non-alcoholic fatty liver disease (NAFLD) Genes involved in the GSH biosynthesis pathway were significantly downregulated in the livers of mice fed an HFD compared to those of mice fed a healthy diet (controls) (Fig

In 1970, the successful application of this method for determination of the diffusion coefficients of haemocyanin at low concentration was reported by Foord et al

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The increased oxidative stress seems to be the second hit in the progression from NAFL to NASH: the increase in ROS and consequently in lipid peroxidation has been associated to hepatocellular damage, inflammation, and eventual fibrosis due to the activation of hepatic stellate cells