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Thus, cholinergic neurotransmission and ACh-dependent regulation of non-neuronal cells employ ThDP coenzyme function for ACh synthesis and non-coenzyme action of thiamine in ACh signaling

2015 This is early preclinical data from one animal model

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An important functional difference between these conditions and G6PD deficiency is that the former result from mutations in tissue-specific genes, whereas Gd is a housekeeping gene