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B12 is water soluble, which means B12 doesnt build up in your system once youre at the appropriate amount for your body you will just eliminate any extra, so theres very little risk of an overdose
Adjunct alongside a GLP-1 , where B12 or nutrient repletion is independently indicated
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Gastrointestinal effects: the main titration bottleneck Nausea, diarrhea, constipation, and vomiting run around 40 to 44% overall, dose-dependent in how many people report them but mild-dominant in severity: severe events stay at or below about 1.7% in any category even at the top dose. In the obesity program the by-dose rates run nausea 25/29/28%, diarrhea 19/21/23%, and vomiting 8/11/13% at 5/10/15 mg. They concentrate during escalation and ease with time on a held dose
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