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Oxidative stress and endothelial dysfunction in hypertension

The GPx family and its members GPxs are members of a multiple-isozyme family that catalyze the reduction of H 2 O 2 or organic hydroperoxides to generate water or corresponding alcohols using reduced glutathione (GSH) as an electron donor [11]

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Then, we can revisit in detail how changes in NUDT15 or TPMT activity influence metabolite levels and drug efficacy, and possibly reset therapeutic thresholds