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Current incretin therapies are limited to injectable options or an oral peptide formulation (oral semaglutide) that includes absorption enhancers and mandates fasting conditions for adequate absorption

Semaglutide is used most often as a diabetes medication

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The clinical expert consulted by CADTH on this review did note that, in their experience, if patients are seeing a benefit from drug therapy, they are more likely to put up with the GI side effects and that GI side effects do tend to improve with time or can be managed with a more gradual dose escalation than that stated in the product monograph

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