DMF stabilizes NRF2, enhances NRF2-dependent transcriptional activity, and upregulates classical target genes such as NQO1 ( Results from pivotal phase III trials demonstrated that DMF significantly reduced relapse rates, delayed disability progression, and lowered MRI lesion activity in patients with RRMS ( 5 Discussion Although currently approved DMTs have substantially improved the management of MS, important unmet needs remain, particularly with respect to progressive disease, neuroprotection, and long-term disability prevention
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