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These effects explain why patients often experience reduced cravings and a natural decline in caloric intake

Traditional thinking viewed glucagon as counterproductive for blood sugar control since glucagon signals the liver to release stored glucose, raising blood sugar levels

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Findings: RCTSURMOUNT-MAINTAIN - Tirzepatide for Maintenance of Bodyweight Reduction in Obesity, Lancet (2026) [PubMed abstract] Design: Randomized, placebo-controlled trial (N=378 | length = 112 weeks) in adults with obesity who completed 60 weeks of open-label tirzepatide at the maximum tolerated dose (10 or 15 mg once weekly) Treatment: Continue tirzepatide maximum tolerated dose (MTD