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Without these, the benefits are often reduced or temporary

Some telehealth providers offer compounded versions (e.g., semaglutide), which may be cheaper but lack FDA approval

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Additional tirzepatide safety concerns include risk of acute gallbladder disease (presenting as right upper quadrant pain, fever, or jaundice), acute kidney injury from dehydration (especially if severe gastrointestinal symptoms occur), and hypersensitivity reactions