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Generally, it'sconsidered to have a high safety profile in preclinical research with no acute toxicity observed, but potential downsides exist

Angeli JPF, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ et al (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

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Wei and Van Griensven, 2008)