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Incidence is on the rise, driven in part by the close association of NAFLD with insulin resistance, diabetes, and obesity, all of which are increasing globally

Conversely, low-dose GLP-1 therapy is not appropriate for patients without established indications, particularly those seeking anti-inflammatory effects alone without diabetes or obesity

They also discussed challenges with conducting a larger study due to the lack of a specific ICD-10 diagnostic code for NAION

A meta-analysis of randomized controlled trials in the Journal of Psychopharmacology found that using folate dietary supplements as an adjunct therapy increased serum folate and significantly reduced depression ratings

Therefore, early phenotype prediction is warranted, but this is complicated as most lcFAODs lack a clear genotype-phenotype correlation