Pharmacological GLP-1RA Action Key Mechanistic Distinctions A comprehensive review published in Cell Metabolism reviewed circuits engaged by endogenous versus pharmacological GLP-1 action, highlighting key GLP-1R-positive cell types and pathways transducing metabolic and non-glycaemic GLP-1 signals
Disclosures: Thi Nga Ha: Nothing to Disclose, Hyon-Seung Yi: Nothing to Disclose, Dong Wook Choi: Nothing to Disclose 1992 HEPATOCYTE-DERIVED FIBROBLAST GROWTH FACTOR 18 PROMOTES HEPATIC FIBROGENESIS UNDER DIETARY STEATOHEPATITIS IN HEPATOCYTE-SPECIFIC CFLAR DEFICIENT MICE Kyoko Fukuhara 1 Yuichi Tsuchiya 2 SHUNHEI YAMASHINA 1 Xingchen Liu 1 Kazuyoshi Kon 1 Akira Uchiyama 1 Reiko Yaginuma 1 Kei Ishizuka 1 Hiroyasu Nakano 3 Kenichi Ikejima 1 , 1 Juntendo University School of Medicine, 2 Department of Biochemistry Toho University Faculty of Pharmaceutical sciences, 3 Department of Biochemistry Toho University School of Medicine Background: Fibroblast growth factors (FGFs) play a pivotal role in tissue remodeling through regulation of various cellular responses such as proliferation, survival, migration and differentiation
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New GLP-1 drugs could suppress desire for more than just food, study suggests A new study funded by the National Institutes of Health (NIH) has uncovered how a newer class of oral GLP-1 weight-loss drugs could reduce the desire for more than just food
To bypass the skin barrier, several support techniques are being studied, such as: Microneedles: Tiny needles create microchannels in the skin, allowing drugs to enter the bloodstream directly
