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Health regulatory agencies such as the United States Food and Drug Administration (FDA), the European Medicines Agency (EMA), and the Pharmaceuticals and Medical Devices Agency of Japan (PMDA) evaluate data from clinical trials before approving the use of GLP-1 analogs for the treatment of diabetes and obesity

Environ Toxicol Chem

They do not address these secondary clinical considerations directly

Administration of 50 and 100 mg/kg/day of the medication in a male mice demonstrated an effect on GLP-1, while acute administration of the primary ingredients of mate resulted in considerable elevations in GLP-1 levels

Taken together these suggest that although GLP1R agonists may increase the risk of pancreatitis and thyroid cancer in rodents, that it has yet to be confirmed in humans