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The Lancet Psychiatry, 3(8), 760773

Clinical trials have demonstrated varying degrees of weight loss depending on the specific agent and dosage: semaglutide 2.4mg (Wegovy) produces approximately 15% weight loss at 68 weeks, liraglutide 3mg (Saxenda) typically achieves 5-8% weight loss, while tirzepatide has shown up to 20% weight reduction in obesity trials

Molecular analysis confirmed that Dihexa potentiates hepatocyte growth factor (HGF) signaling at the c-Met receptor, promoting synaptogenesis as the proposed mechanism for cognitive improvement

Starting with a lower dose and gradually increasing it helps minimize these issues

The second article was also a case report and found nodule development on the thigh of a 54-year-old man