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Metoclopramide should be used for a maximum of 5 days, whilst domperidone is restricted to short-term use at the lowest effective dose due to potential side effects and contraindications
For example, Oeseberg showed that dipeptidyl-peptidase 4 (DPP-4) inhibition significantly reduced vascular senescence in a diabetic rat model
Considering dopamines pivotal role in the brains reward system, such alterations could lead to an imbalance in dopaminergic neurotransmission 43,44
There are many oral and injectable options now that are FDA-approved, so its best to stick with medications that have been assessed by the standard safety/efficacy channels
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