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Common symptoms include: Hematologic : Macrocytic (megaloblastic) anemia Pallor and shortness of breath on exertion Neurological : Paresthesias (tingling, pins and needles) in hands and feet Gait disturbances and balance problems Cognitive changes: memory lapses, brain fog, mood swings Gastrointestinal : Glossitis (inflamed tongue) Appetite loss and weight changes Nausea or diarrhea Because the nervous system can be permanently damaged if deficiency persists, early detection and correction are paramount

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The myotendinous junction studies (Japjec et al., 2021, Biomedicines ) extended the tendon work to the muscle-tendon interface, showing accelerated healing of disabled junctions in rats