Usually it is a good enough indicator to compare different models from the same brand, but I would not compare C ratings of different brands with each other, or at least only see it as a ballpark range
Turbulent flow promotes NF-B and AP-1 activity that upregulate pro-inflammatory and pro-atherogenic genes such as ICAM-1, E-selectin, platelet-derived growth factor (PDGF)-BB, IL-1a, bone morphogenic protein-4 (BMP-4), monocyte chemotactic protein-1 (MCP-1), and ET-1 [211]
Kerlikowske K, Zhu W, Tosteson ANA, et al
For instance, dietary changes can rapidly alter microbial populations, with high-fiber intake promoting beneficial bacteria proliferation in the short term
Many users simply cannot eat enough in a six-hour window when appetite is pharmacologically blunted