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[25] Tretinoin, the all-trans retinoic acid isomer, diffuses through the stratum corneum and binds intracellular retinoic acid receptors (RAR-, , ), forming heterodimers with RXR that trans-activate genes governing keratinocyte differentiation, desmosomal degradation, and collagen synthesis

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For example, prebiotics such as fructose oligosaccharides and galactose are able to significantly promote the proliferation of Bifidobacteria and Lactobacillus , while inhibiting the growth of harmful bacteria such as Clostridium and Escherichia coli (Wang K

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Thus, you need to consume the right amount of B12 daily if you want to avoid a vitamin B12 deficiency