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These limitations dont invalidate the positive safety findings but do suggest that comprehensive medical supervision remains appropriate for anyone using AOD-9604, particularly for off-label applications or extended treatment periods

This study was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) checklist (Supplementary Table 1)

1 MS: molar substitution, corresponds to hydroxy propyls per glucose uni Preparation process Formulations were prepared as described in example 1

7,8 Postmortem analyses further identified astrocytes as the source of this dysregulation, with increased MAOB-mediated GABA synthesis and reduced ABAT-mediated degradation as key underlying mechanisms (Study 3)