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doi: 10.7759/cureus.68339 42

Approximately 2% of the oxygen consumed by the mitochondria is converted into superoxide, making it one of the largest sources of endogenous ROS ( via -oxidation of fatty acid and flavin oxidase reaction and degrading ROS via catalase-mediated breakdown of H 2 O 2 ( Table 1 Formation of major oxidants

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(10) Studies have documented that IGF-1 signaling promotes fibroblast proliferation, collagen synthesis, and angiogenesisall critical components of wound healing