glp 1 diarrhea mechanism Frontiers Adverse effects of GLP-1 class

Based on Bell's findings, Holst and his colleagues knew that the sequence of human proglucagon was made up of 180 amino acids and that they had predicted that when translated it potentially cleaved into two peptides made up of 36 and 35 amino acids, respectively designated GLP-1 (1-36) and GLP-2 (rskov, Holst, Seier Poulsen, Kirkegaard

doi: 10.3390/jpm12050673, 188

While gene therapy is available for a small subset of patients with specific mutations, developing a therapeutic that broadly targets the cellular stresses that lead to cell death could address a major unmet need

doi: 10.1016/j.hrtlng.2016.12.004

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