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Today, migraine is viewed as a result of complex dysfunction within the central nervous system (Charles 2009)

doi: 10.3389/fimmu.2015.00627 83 WaldeckerMKautenburgerTDaumannHBuschCSchrenkD

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Consequently, long-term CM may contribute to a healthier intestinal microbiota, potentially improving gut-brain communication through multiple mechanisms, including microbiota regulation (335)