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Approved by the FDA in October 2006, and branded as Januvia, the drug soon became one of Merck's most successful drugs

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CLA and Body Composition: What the Clinical Evidence Actually Shows A systematic review and meta-analysis published in the American Journal of Clinical Nutrition (PubMed PMID 17636085) found that CLA supplementation produced a small but statistically significant reduction in body fat mass, with an average fat loss of approximately 0.09kg per week more than placebo groups across multiple controlled trials

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however, it has been shown that GLP-1 has direct effects on certain neurons in the hypothalamus