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Reasons active-duty service members listed for smoking included: 5 Stress: 47.7%

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This result is consistent with the function of TDCA which has been reported as a ligand to activate MAPK/ERK pathway.26 27 The activation of MAPK/ERK pathway is important for cell proliferation35 and was proved to be involved in the pathogenesis, progression and oncogenesis of human CRC.36 Moreover, we found that proinflammatory IL-17 and TNF pathways were induced by cigarette smoke