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Dihexa shows cognitive enhancement at picomolar concentrations, making it approximately ten million times more potent than brain-derived neurotrophic factor in some synaptogenesis assays

"Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice." Biogerontology

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On the other hand, oral supplements have to go through the gastrointestinal tract

We observed a change in fluorescence lifetime from 1.3 ns in an NADP + -saturated state to 2.3 ns in an NADPH-saturated state, which is exceptionally large for a fluorescent protein-based biosensor