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In the clinical experience of some authors of this Advisory, another approach is to maintain individuals at the lowest effective dose and escalate only as needed (i.e., when weight reduction ceases or efficacy wanes), although shortages of medications at lower doses may be a barrier

Hurtado MD, Tama E, Fansa S, Ghusn W, Anazco D, Acosta A, et al

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150 There is also a great interest in the novel approaches that have the possibility of becoming vital therapeutic targets, such as TLRs

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