Notably, the effects of a GLP-1 receptor agonist during anticipatory and consummatory phases of food reward revealed opposing changes in brain responses, reducing anticipatory while enhancing consummatory reward responses (van Bloemendaal et al., 2015a)
Effects on classic cardiovascular risk factors CVOTs on GLP-1RAs Data from the major CVOTs ELIXA, SUSTAIN-6, EXSCEL, HARMONY, PIONEER 6, LEADER, REWIND, and AMPLITUDE-O [53, 54, 56, 59,60,61,62,63] support the overall safety of GLP-1RAs relative to major cardiovascular outcomes
If you or someone you love is struggling with alcohol use and also meets criteria for a GLP-1 prescription (typically type 2 diabetes or a BMI over 30), its worth having a conversation with a healthcare provider about whether these medications might serve a dual purpose
Low-grade metabolic acidosis and overt metabolic acidosis (serum bicarbonate below 22 mmol/L) increase the risk of kidney stone formation (Wieers 2024)
Wegovy is also a brand name for semaglutide and is FDA-approved for weight loss
