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Mounjaro is for type 2 diabetes, while Zepbound is for chronic weight management, ideal for individuals with obesity or weight-related conditions like high blood pressure

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Given the dose-dependent effects and improved management of tolerability within the GLP-1RA class, the aim of this trial was to characterize the dose-dependent effects of subcutaneous semaglutide at doses up to 16 mg weekly (2 mg, 8 mg, 16 mg, and pooled placebo) in individuals with type 2 diabetes and overweight or obesity (BMI 27 kg/m 2 )

These include: Nausea very common (may affect more than 1 in 10 people) Vomiting and diarrhoea common (may affect up to 1 in 10 people), especially when starting treatment or increasing the dose Abdominal pain and bloating related to the slowing of gastric emptying Reduced appetite common and may contribute to weight reduction Constipation common according to the product information These gastrointestinal symptoms are usually mild to moderate and often improve over time as the body adapts to the medication

All participants provided written informed consent before undertaking trial-related activities