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While we recognize the challenges some clinicians face, as cited by the commenters, we believe that introducing a model that would incentivize improved upstream chronic condition management through two-sided risk is appropriate given the high prevalence and high spending related to ASM's targeted chronic conditions

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This dual-receptor activity offers an enhanced therapeutic effect: Amplified Insulin Secretion: By engaging both GLP-1 and GIP pathways, tirzepatide stimulates an even more robust insulin response to glucose, leading to superior blood sugar control