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Patients should be counseled to monitor urine color (pale yellow indicating adequate hydration) and to increase fluid intake during exercise or hot weather

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Patients with RA with CKD have an increased risk of cardiovascular disease regardless of other classical CVD risk factor, and the decrease in kidney function limits RA treatment options (161, 162)

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Additional experimental models incorporating glucose tolerance testing and fasting biomarker analysis show no significant changes in plasma glucose or insulin levels following exposure to AOD 9604