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Because GLP-1 drugs suppress appetite and slow digestion, they can also reduce nutrient intake and alter how nutrients are absorbed

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Additionally, GLP-1 receptor agonists slow gastric emptying , which moderates the rate at which glucose enters the bloodstream after meals

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The SURMOUNT-4 trial showed even steeper rebounds with tirzepatide, with participants regaining more than 50% of their weight loss over 52 weeks after stopping