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In dermaroller group, none of the patients had hyperpigmentation, whereas in the case of copper peptide group, 8 (40%) had hyperpigmentation and 12 (60%) reported no side effects

Detailed clinical records were systematically maintained for all participants at the respective outpatient units

Titration over weeks

The concurrent engagement of all three receptors is hypothesised to produce complementary metabolic effects in pre-clinical models: GLP-1R activation is associated with glucose regulation and appetite modulation, GIPR activation with potentiation of GLP-1mediated responses, and GcgR activation with energy expenditure and hepatic lipid metabolism in laboratory settings

Pathophysiological Mechanisms Explaining the Association Between Low Skeletal Muscle Mass and Cognitive Function