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Figure 5 2.2.4 GTP cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4) The GCH1/BH4 pathway is an intracellular enzymatic pathway involved in various crucial cellular metabolic processes ( 2.2.5 Others Currently, there are multiple endogenous defense pathways in cells to counteract ferroptosis, including GSH-GPX4 , FSP1-CoQ1 , DHODH-CoQ10 , GCH1-BH4 , as well as MBOAT1/2 ( GPX4 or FSP1 ( MBOAT1 and MBOAT2 is upregulated by estrogen receptor (ER) and androgen receptor (AR), respectively

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