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They cause massive reductions in metabolic rate, break down muscle (which is also important for normal metabolic function), and are almost never effective long-term

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Chronic exposure to these drugs depletes presynaptic monoamine stores, impairs long-term neuronal signaling, and induces neurodegeneration ( 4.2 Oxidative stress and mitochondrial dysfunction The excessive release of monoamines promotes ROS formation through the auto-oxidation of dopamine and norepinephrine

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Ferrucci, L (May 2009)