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Higher doses or additional medications Repeated injections without sustained improvement Increasing side effects with diminishing therapeutic return At this stage, pain is no longer simply a symptomit reflects underlying regulatory imbalance

This concept has been reframed through the lens of allostasis, in which there is a progressive overload of metabolic systems in response to chronic nutrient excess

Fatigue may be a medication side effect or an indication of a drug interaction

Another of the attendees, Dave Asprey, author and self-proclaimed father of biohacking, gave a talk on the secrets of brain longevity and declared that he intended to live until at least 180

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