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Studies indicate the peptide may stabilize neuronal membrane function and protect against excitotoxicity associated with excessive glutamate signaling during brain injury

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Protoplasma 217:2032 Bordenave CD, Escaray FJ, Menendez AB, Serna E, Carrasco P, Ruiz OA, Grriz A (2013) Defence responses in two ecotypes of Lotus japonicus against non-pathogenic Pseudomonas syringae

A 2024 sponsored study found that L-citrulline demonstrates superior bioavailability for nitric oxide production during physical activity compared to L-arginine, which is why athletes and fitness enthusiasts often turn to this supplement to enhance performance