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GLP-1RAs and clinical trials in NAFLD Lixisenatide In a systematic meta-analysis including 12 randomized controlled trials (RCTs) comparing lixisenatide to placebo or active interventions in T2D, lixisenatide was reported to normalize levels of alanine aminotransferase (ALT) in a greater proportion of overweight and obese patients with T2D than comparators (54)
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Markers of apoptosis, such as CK-18, have been studied, but may not accurately reflect change in histology over time
Efficacy and Safety of Retatrutide, a GIP, GLP-1, and Glucagon Receptor Agonist Once Weekly for Weight Management: A Randomised, Double-Blind, Placebo-Controlled Trial